Pramipexole is the main active ingredient.Different formulations may contain additional inactive ingredients such as fillers, binders, and coatings. Always check the specific product labeling for a complete list of ingredients.
Treatment of Parkinson's disease, including earlystage disease and advanced disease where levodopa is no longer fully effective.
Treatment of restless legs syndrome (RLS).
Plessi-Er 0.375 Tablet (Pramipexole) is a dopamine agonist. It works by mimicking the effects of dopamine, a neurotransmitter that helps control movement and coordination. In Parkinson's disease, dopamine production is reduced. Pramipexole helps to compensate for this deficiency. In RLS, it's believed to modulate dopamine receptors to reduce the urge to move.
Store pramipexole tablets at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Discard any medication that is expired or shows signs of degradation (e.g., discoloration, unusual odor).
Dosage is determined by a physician based on individual needs and response to treatment. It's typically started at a low dose and gradually increased.
Pramipexole is available in different forms (tablets, extended-release tablets) and strengths. Always follow your doctor's prescribed dosage and administration instructions.
Do not stop taking pramipexole suddenly without consulting your doctor; it should be tapered off gradually to minimize withdrawal symptoms.
Nausea
Vomiting
Dizziness
Sleepiness
Hallucinations
Constipation
Insomnia
Fatigue
Swelling of the limbs (edema)
Avoid alcohol consumption while taking pramipexole, as it can increase the risk of drowsiness and dizziness.
Avoid driving or operating machinery until you know how pramipexole affects you. Drowsiness and dizziness are potential side effects.
Consult your doctor before taking pramipexole if you are pregnant, breastfeeding, or plan to become pregnant. Pramipexole may pose risks to a developing fetus or infant.
Pramipexole is generally not recommended for children unless specifically prescribed by a physician for a condition approved in children.
Kidney impairment may affect the dosage and elimination of pramipexole. Your doctor will adjust your dose accordingly.
Liver impairment may affect the dosage and elimination of pramipexole. Your doctor will adjust your dose accordingly.
Your doctor or pharmacist.
The prescribing information provided with your medication.
Reputable medical websites (e.g., Mayo Clinic, National Institutes of Health).
