Prescription Required.Why?
An alkaloid derived from the rauwolfia serpentina plant, acting as a centrally acting alpha-adrenergic blocker and depleter of catecholamines.
A vasodilator that relaxes blood vessels, primarily acting on arterioles.
A thiazide diuretic that increases urine output, helping to lower blood volume and blood pressure.
Treatment of severe hypertension (high blood pressure) that has not responded adequately to other medications.
Management of hypertensive crises
This combination medication works through a synergistic effect of its components. Reserpine reduces sympathetic nervous system activity by depleting norepinephrine, leading to decreased vascular resistance. Dihydralazine directly relaxes arterioles, lowering peripheral resistance. Hydrochlorothiazide promotes diuresis, reducing blood volume and further contributing to blood pressure reduction. The combined action provides a more effective control of severe hypertension than any single agent.
Store at room temperature (20-25°C) in a tightly closed container, away from moisture and direct sunlight. Keep out of reach of children. Discard any unused medication after the expiry date.
Dosage is strictly individualized and determined by a physician based on the patient's response and tolerance. It is crucial to follow the prescribed dosage regimen precisely.
Medication should be taken as directed by your doctor. Never abruptly stop taking the medication without consulting your physician.
The usual dose is administered orally.
Drowsiness or sedation
Nausea and vomiting
Diarrhea
Headache
Dizziness
Depression
Nasal congestion
Fluid and electrolyte imbalances (hypokalemia, hyponatremia)
Breast enlargement (gynecomastia)
Lupuslike syndrome (rare)
Alcohol consumption should be minimized or avoided completely as it can enhance the hypotensive effects of the medication and increase the risk of side effects.
Patients should exercise caution while driving or operating machinery due to potential drowsiness and dizziness.
Use during pregnancy and breastfeeding is generally discouraged due to potential risks to the fetus and infant. Consult your physician immediately if pregnancy is suspected or planned.
Generally not recommended for use in children due to the lack of safety data. Specific considerations from a pediatrician are needed.
Caution is advised in patients with impaired kidney function as the medication may accumulate and lead to side effects. Dosage adjustments may be necessary.
Caution is advised in patients with liver impairment as drug metabolism may be affected. Dosage adjustments may be necessary.
Consult your physician or pharmacist for detailed information and specific references related to your individual case.
Refer to your medication package insert for detailed product information
