Methotrexate

Is the main active ingredient. specific formulations may contain additional inactive ingredients like preservatives, fillers, and stabilizers. always check the product label for a complete list of ingredients.

Rheumatoid arthritis

Psoriatic arthritis

Juvenile idiopathic arthritis

Certain types of cancer (e.g., choriocarcinoma, lymphoma, leukemia)

Severe psoriasis

Ectopic pregnancy

Extrate 2.5mg Tablet (Methotrexate) interferes with the growth of rapidly dividing cells, including cancer cells and cells involved in inflammation. It works by inhibiting an enzyme (dihydrofolate reductase) essential for DNA synthesis, thus slowing or stopping cell division.

Store methotrexate as directed on the prescription label, typically at room temperature away from moisture and light. Keep it out of reach of children and pets. Do not use after the expiration date.

Dosage is determined by your doctor based on your condition, weight, and response to treatment.

Methotrexate can be administered orally (as tablets or solution), intravenously (IV), or intramuscularly (IM).

Never change your dose or stop taking methotrexate without consulting your doctor.

Nausea

Vomiting

Diarrhea

Mouth sores

Fatigue

Headache

Hair loss

Liver damage

Kidney damage

Increased risk of infection

Alcohol Consumption

Avoid alcohol consumption while taking methotrexate, as it can increase the risk of liver damage.



While Driving or operating Machinery

Methotrexate may cause drowsiness or fatigue. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Methotrexate is contraindicated during pregnancy due to teratogenic effects. Breastfeeding is generally discouraged during treatment. Consult your doctor immediately if you become pregnant or are planning to become pregnant while using this medication.



Children

Use in children is only under strict medical supervision and at specific doses.



Kidney

Methotrexate can be harmful to the kidneys; kidney function should be monitored regularly.



Liver

Methotrexate can cause liver damage; liver function should be monitored regularly. Patients with pre-existing liver disease should exercise caution.

Your physician or pharmacist

The FDA drug label

Reputable medical websites such as the National Institutes of Health (NIH)