Methotrexate

Methotrexate (the active ingredient)Inactive ingredients (vary depending on formulation – check product packaging)

Rheumatoid arthritis

Psoriatic arthritis

Juvenile idiopathic arthritis

Ankylosing spondylitis

Certain types of cancer (e.g., leukemia, lymphoma)

Severe psoriasis

Ectopic pregnancy (in specific circumstances under medical supervision)

Methoace 1000mg Injection (Methotrexate) inhibits dihydrofolate reductase, an enzyme essential for DNA synthesis. This interferes with cell division and growth, slowing the progression of inflammatory diseases and cancerous cells.

Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children. Do not use if the medication is expired or shows signs of deterioration.

Dosage varies greatly depending on the condition being treated and the patient's individual needs.

It may be administered orally, intravenously, or intramuscularly.

Dosage should be determined and monitored closely by a healthcare professional.

Never adjust the dose yourself without consulting your doctor.

Nausea

Vomiting

Diarrhea

Mouth sores

Hair loss

Fatigue

Liver damage

Kidney damage

Bone marrow suppression

Infections

Pneumonitis

Severe allergic reactions

Alcohol Consumption

Alcohol consumption should be minimized or avoided entirely while taking methotrexate, as it can increase the risk of liver damage.



Driving or Operating Machinery

Methotrexate can cause fatigue and other side effects that may impair judgment or coordination. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Methotrexate is teratogenic (causes birth defects) and should not be used during pregnancy or breastfeeding unless strictly necessary and under close medical supervision. Reliable contraception is crucial.



Children

Use in children is only appropriate under strict medical supervision due to potential developmental side effects.



Kidney

Methotrexate can impair kidney function. Kidney function should be monitored regularly during treatment.



Liver

Methotrexate can cause liver damage; liver function should be monitored regularly, and alcohol should be avoided.

Your doctor or pharmacist

The medication's package insert

Reputable medical websites (e.g., Mayo Clinic, NHS)