Prescription Required.Why?
A selective serotonin reuptake inhibitor (ssri) antidepressant.
A benzodiazepine used as an anti-anxiety medication and anticonvulsant.
Treatment of major depressive disorder (MDD) with significant anxiety symptoms.
Management of panic disorder with or without agoraphobia.
Shortterm relief of severe anxiety.
Offlabel use in some cases of generalized anxiety disorder (GAD), but usually not the first-line treatment.
Paroxetine increases serotonin levels in the brain by blocking its reuptake, improving mood and reducing anxiety. Clonazepam enhances the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve impulses, reducing anxiety and promoting relaxation. The combination provides both a longer-term mood elevation (paroxetine) and immediate anxiety relief (clonazepam).
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Dispose of unused medication properly according to local regulations.
Dosage is determined by a physician and is highly individualized based on the patient's condition and response to treatment.
The combination is typically started with low doses of both medications, gradually increased as needed.
Never adjust the dosage on your own; always consult with your doctor.
Withdrawal symptoms upon abrupt discontinuation (especially clonazepam)
Nausea
Drowsiness
Dizziness
Dry mouth
Constipation
Headache
Insomnia or excessive sleepiness
Weight changes
Sexual dysfunction
Alcohol should be avoided or severely limited as it can potentiate the sedative effects of both medications, increasing the risk of falls, accidents, and impaired judgment.
Avoid driving or operating machinery until you know how this medication affects you. Drowsiness and impaired coordination are possible side effects.
Consult your doctor immediately. Both medications can pose risks to the fetus or infant. Alternative treatments may be considered.
Generally not prescribed for children, except in specific circumstances under strict medical supervision.
May require dosage adjustments in patients with kidney impairment.
May require dosage adjustments in patients with liver impairment.
Your doctor and pharmacist
Prescribing information provided by the medication manufacturer
Reputable medical websites and journals (e.g., Mayo Clinic, UpToDate)
