Prescription Required.
Is the active ingredient.
Treatment of mild to moderate idiopathic pulmonary fibrosis (IPF).
The exact mechanism of Pirfenex 600mg Tab (Pirfenidone) in IPF is not fully understood. However, it's believed to work through multiple pathways, including anti-inflammatory, antifibrotic, and antioxidant effects. It may reduce the production of transforming growth factor-beta (TGF-β), a key cytokine involved in fibrosis.
Store at room temperature (20°C-25°C) in a tightly closed container, away from moisture and direct sunlight. Keep out of reach of children.
The usual starting dose is 801mg three times daily (2403mg total daily dose) with food.
The dose may be increased to 2403mg per day, administered 801mg three times daily. This will only happen after physician assessment of tolerability after at least 1 week on the lower dose
Follow your doctor's instructions carefully and do not change the dosage without consulting them.
Nausea
Diarrhea
Fatigue
Loss of appetite
Photosensitivity (increased sensitivity to sunlight)
Rash
Weight loss
Headache
Dizziness
Gastrointestinal upset
Limit or avoid alcohol consumption as it may increase the risk of liver damage.
Pirfenidone may cause dizziness or fatigue. Avoid driving or operating machinery if affected.
Pirfenidone is not recommended during pregnancy or breastfeeding. Consult your doctor immediately.
Safety and efficacy in children have not been established.
Caution is advised in patients with moderate to severe kidney impairment. Dose adjustment may be necessary.
Pirfenidone can affect liver function; regular liver function tests are usually required during treatment. Discontinue use if significant liver enzyme elevation occurs.
Prescribing information provided by the pharmaceutical manufacturer.
UpToDate
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